20, 641649. Image Biomarker Standardisation Initiative, Minimum redundancy maximum relevance with selection of 10 features, Minimum redundancy maximum relevance with selection of 20 features. Skoetz N, Will A, Monsef I, Brillant C, Engert A, von Tresckow B. Cochrane Database Syst Rev. Please enable it to take advantage of the complete set of features! DS gives the threshold for adequate or inadequate response to be adapted according to the clinical context or research question. Positron emission tomography/computed tomography should be used to determine the staging of the lymphoma. SUV max reduction (SUV max) and tumor/liver ratio (TLr) are promising tools for response assessment in lymphoma.We determined the optimal cutoff values for SUV max and TLr and CT radiomics to predict Deauville score 4 positive and negative Hodgkin lymphoma manifestations, https://doi.org/10.1038/s41598-022-24227-0. See further details. also attempted to extract prognostic information from non-contrast-enhanced CT scans of patients with Hodgkins lymphoma and aggressive Non-Hodgkin lymphoma complementary to interim FDG-PET/CT. Defining a Hodgkin lymphoma population for novel therapeutics after relapse from autologous hematopoietic cell transplant. The authors declare no conflict of interest. (reader 1: board-certified radiologist with over nine years of experience, reader 2: radiology resident with more than four years of experience). PET/CT (b,c) show this manifestation to be FDG-positive. 2023 Standard of Care. Epub 2016 Jul 4. J Clin Oncol. Rep. 10, 11649. https://doi.org/10.1038/s41598-020-68310-w (2020). WebDeauville Criteria Deauville 1: No FDG uptake Deauville 2: FDG uptake < or = mediastinal blood pool Deauville 3: FDG uptake > mediastinal blood pool and < or = normal liver parenchyma Deauville 4: FDG uptake greater than normal liver parenchyma Deauville 5: FDG uptake significantly greater than normal liver parenchyma or new FDG-avid lesions However, NCCN imaging guidelines for lymphoma surveillance state that it is acceptable to perform chest radiography or CT of the chest every six to 12 months for the first two years and then yearly for the next three to five years posttreatment.41 Surveillance imaging with PET-CT scans following complete remission is not recommended.40,41 Disease marker research is ongoing, examining minimal residual disease measurements, a polymerase chain reactionbased method that looks at identifying tumor-specific DNA sequences.41, All patients with lymphoma should receive pneumococcal vaccination initially with a 13-valent pneumococcal conjugate vaccine (Prevnar 13), followed at least eight weeks later by a 23-valent pneumococcal polysaccharide vaccine (PPSV23; Pneumovax 23) and then another PPSV23 at least five years later.44 Patients receiving antiB-cell antibodies should not receive annual influenza vaccination, and administration of live vaccines is contraindicated during chemotherapy. Ibrahim, F.; Gabelloni, M.; Faggioni, L.; Padma, S.; Visakh, A.R. 2020 Nov 24;4(22):5762-5771. doi: 10.1182/bloodadvances.2020002814. Google Scholar. ; Hudson, M.M. The 1 year PFS was 93.3% and no patient had Cheson, B.D. The portal can access those files and use them to remember the user's data, such as their chosen settings (screen view, interface language, etc. Radiomic features were extracted using PyRadiomics (Version 3.0)25,26, following the instructions of the Image Biomarker Standardisation Initiative (IBSI)27.
Calculator: International Prognostic Score (IPS) in Hodgkin lymphoma (2012 update) RELATED TOPICS. deauville five point scale, lymphoma, t-cell, peripheral, positron-emission tomography, angioimmunoblastic lymphadenopathy, ki-1+ anaplastic large cell lymphoma, cyclophosphamide, doxorubicin, prednisone, and vincristine, follow-up, chemotherapy regimen, diagnostic imaging, lymphoma, non-hodgkin Author notes * The aim is to provide a snapshot of some of the Hussien, A.E. They found that CT density correlated with 18F-FDG uptake, 68Ga-DOTATOC uptake, and 68Ga-PSMA uptake and suggested a Hounsfield scale to differentiate benign from malignant lymph nodes. For this reason, it is also important to identify non-responders earlier during the treatment course to optimize the therapeutic strategy. Our results should be verified in larger, more consistent patient populations examined on CT scanners from additional vendors to affirm median as a robust feature across scanners and should be validated externally according to Shahzadi44 supporting clinical applicability. https://doi.org/10.2967/jnumed.116.179648 (2017). When using the DS method, 31 (71.1%) patients were classified as responders (DS 1, 2 and 3) at interim PET-CT, whereas 47 (90.4%) were classified as responders at post-therapy PET-CT. No patients had a DS of 5 at either the interim or post-therapy PET-CT. Five (9.6%) patients had a DS of 4 after completion of therapy and were treated more aggressively with more cycles of chemotherapy or a change in the regimen and/or field radiotherapy. Google Scholar. N Engl J Med. Blood 132, 22732279. However, a clear tendency towards one texture feature or feature class that distinctly correlates with increased FDG uptake has not emerged yet. Boellaard, R. Standards for PET image acquisition and quantitative data analysis. Imaging Biol. Non-Hodgkin lymphoma is treated with CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone) with or without rituximab (R-CHOP), bendamustine, and lenalidomide. 6, 8. https://doi.org/10.1186/s40658-019-0244-0 (2019). Article PET/CT scans were performed between September 2015 and March 2019. Aims: We aimed to validate DS in Hodgkin's lymphoma (HL) by retrospectively assigning this score to F-18 FDG PET-computed tomography (CT) studies done before 2016 and analyzing its concordance with the line of management. Med. Considering the results of the MWU test, 41 features from the dataset of scanner A and eight from the dataset of scanner B showed a significant difference between DS4-positive and DS4-negative lesions. Hello I want to change document wide default font. Bhatia, S.; Yasui, Y.; Robison, L.L. Annunziata, S.; Cuccaro, A.; Calcagni, M.L. https://CRAN.R-project.org/package=psych. PET/CT mediastinal and liver FDG uptake: Effects of biological and procedural factors. https://www.mdpi.com/openaccess. ; Erdrich, A.S.; Hundsdoerfer, P.; Ruf, J.; Henze, G.; Schnberger, S.; Amthauer, H.; Hautzel, H. Explorative analyses on the value of interim PET for prediction of response in pediatric and adolescent non-Hodgkin lymphoma patients. ; methodology, S.N.N., J.M.M.R., I.G.S. For example, Mayerhoefer et al. PET data were acquired from the skull base to the proximal femora in 3D acquisition mode (acquisition time, 23min per bed position). Milgrom, S. A. et al. ; Schwartz, L.H. As an alternative, we investigated radiomics from non-contrast-enhanced computed tomography (NECT) scans. ; Kluge, R. FDG PET for therapy monitoring in Hodgkin and non-Hodgkin lymphomas. and JavaScript. pROC: An open-source package for R and S+ to analyze and compare ROC curves. Sci Rep 12, 20008 (2022). Informed consent was obtained from all subjects involved in the study. The relevant cutoff was between DS3 and DS4 and defined by a qPET value of 1.323: lesions equal or above were classified as DS4-positive, lesions below as DS4-negative. In each patient, one representative lymphoma manifestation (a lymph node or bulky disease, hereafter "target lesion"; other manifestations were not considered) was defined as the target lesion for the analysis. Required fields are marked *. 2018 Dec;24(12):2501-2508. doi: 10.1016/j.bbmt.2018.07.025. Prognostic significance of interim PET/CT response for the treatment of advanced-stage marginal zone lymphoma in the post-rituximab era. Revelle, W. psych: Procedures for Psychological, Psychometric, and Personality Research. Scores of 1 and 2 are considered to be negative and 4 and 5 are considered to be positive. Semin. ; Birch, J.M. PET data from scanner B were reconstructed iteratively with Bayesian penalized likelihood reconstruction (GE Q.Clear) with a penalization factor of 450, which included time of flight analysis and point spread function modeling21. Approximately 82,000 new U.S. patients are diagnosed with lymphoma annually. Prognostic significance of baseline metabolic tumor volume in relapsed and refractory Hodgkin lymphoma. FDG-PET/CT images were acquired on two different scanners: Scanner A (Gemini TF 16; Philips Medical Systems, Hamburg, Germany)19 and scanner B (Discovery MI; GE Medical Systems, Chicago, USA)20. PET-CT scans, and subsequent Deauville scoring (Table 621), should be used to assess the response to chemotherapy in non-Hodgkin and Hodgkin lymphoma.25,30,31,33 A score of 3 or less is considered complete remission in non-Hodgkin lymphoma and should conclude the current treatment course. ; Mostafa, H.M.; Elsayed, H.F.; Abo-ElAzm, O.M. The Spearman between Deauville score and SUV max approach was 0.31 (95% CI, 0.230.38). Nucl. BREACH is a multicenter, randomized, open-label, phase II trial. Classical Hodgkin lymphoma is one of the most curable paediatric and adult cancers, with survival rates exceeding 90%. National Library of Medicine Further classification of distinct lymphoma subtypes is beyond the scope of this article; however, they are ultimately each defined by morphology, immunopheno-type, genetic, molecular, and clinical features.1,3 This article will focus on the types of lymphoma traditionally classified as non-Hodgkin or Hodgkin. Younes A, Connors JM, Park SI, Fanale M, O'Meara MM, Hunder NN, Huebner D, Ansell SM. Sci. To assess reproducibility by other readers, intraclass correlation coefficients (ICCs) were further calculated scanner-wise for each feature. The conventional surgical procedure for lung adenocarcinoma is lobotomy with systematic mediastinal Prognostic value of pretreatment radiomic features of 18F-FDG PET in patients with hodgkin lymphoma. https://doi.org/10.1053/j.semnuclmed.2017.09.007 (2018). ; Mauch, P.M. ; Klokman, W.J. Visit our dedicated information section to learn more about MDPI. and transmitted securely. Comparison of commonly used SUV metrics for differentiation between paediatric tumours. Details of the patients are summarized in Table 1. Paper should be a substantial original Article that involves several techniques or approaches, provides an outlook for Accessibility ; data curation, S.N.N., L.J.J., J.R., I.G.S. ; validation, C.F.,H.A. CAS Progression-free survival (PFS) was well stratified according to a visual assessment of interim PET/CT using 5-PS (p < 0.001). ROC curves of these features are presented in Fig. sharing sensitive information, make sure youre on a federal Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Jorgov, L.; Montravers, F.; Balogova, S.; Ragu, C.; Pacquement, H.; Leblanc, T.; Abbou, S.; Ducou-Lepointe, H.; Landman-Parker, J.; Talbot, J.N. Kluge, R. et al. Post-therapy DS showed a sensitivity, specificity, PPV, NPV and accuracy of 66.7%, 97.8%, 95.7%, 80% and 94.2%, repsectively. A metaanalysis of 18F-2-deoxy-2-fluoro-D-glucose positron emission tomography in the staging and restaging of patients with lymphoma. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. Unauthorized use of these marks is strictly prohibited. 14, 749762. Leuk Lymphoma. Any tobacco use and obesity are major modifiable risk factors, with genetic, infectious, and inflammatory etiologies also contributing. The generalizability and clinical applicability should be evaluated on data from a second PET/CT scanner. FOIA However, if the lesion was difficult to delineate on the NECT images, the lesion with the next lower or comparable DS was considered. Role of imaging in the staging and response assessment of lymphoma: Consensus of the International Conference on Malignant Lymphomas Imaging Working Group. Internet Explorer). Baseline PET/CT imaging parameters for prediction of treatment outcome in Hodgkin and diffuse large B cell lymphoma: A systematic review. Feature papers are submitted upon individual invitation or recommendation by the scientific editors and must receive Since these are acquired shortly before the PET images, this results in only a short temporal gap to the reference standard. Role of imaging in the staging and response assessment of lymphoma: Consensus of the International Conference on Malignant Lymphomas Imaging Working Group. Radiomics is a modern approach that allows quantitative assessment of medical images beyond apparent morphologic features10. The feature median showed a high sensitivity for DS4+ manifestations on both scanners (scanner A: 0.91, scanner B: 0.85). Applied logistic regression. Radiol. Lancet Oncol. https://doi.org/10.1182/blood-2018-05-852129 (2018). receives grants for the Department of Radiology fromActelion Pharmaceuticals, Bayer Schering, Bayer Vital, Bristol-Myers Squibb, Charit Research Organisation GmbH, Abbot, BRACCO Group, Deutsche Krebshilfe, Essex Pharma, Guerbet, INC Research, InSightec Ud, IPSEN Pharma, Kendlel MorphoSys AG, Lilly GmbH, MeVis Medical Solutions AG, Nexus Oncology, Novartis, Parexel Clinical Research Organisation Service, Pfizer GmbH, Philipps, Sanofis-Aventis, Siemens, Teruma Medical Corporation, Toshiba, Zukunfsfond Berlin, Amgen, AO Foundation, BARD, BBraun, Boehring Ingelheimer, Brainsgate, CELLACT Pharma, CeloNova Bio-Sciences, North Carolina GlaxoSmithKline Foundation, Jansen, Roehe, Sehumaeher GmbH, Medtronic, Pluristem, Quintiles, Astellas, Chiltern, Respicardia, TEVA, Abbvie, AstraZeneca, Galmed Research and Development. Imaging 41, 13011308. Author disclosure: No relevant financial affiliations. 2022 Nov 1;14(21):5390. doi: 10.3390/cancers14215390. Cite this article. EJNMMI Phys 7, 2. https://doi.org/10.1186/s40658-020-0270-y (2020). The Infona portal uses cookies, i.e. We assessed the efficacy and safety of brentuximab vedotin plus doxorubicin, vinblastine, and dacarbazine (BV-AVD) in previously untreated, early-stage unfavorable Hodgkin lymphoma (ClinicalTrials.gov identifier: Google Scholar. This was a retrospective study involving 52 patients (male:female 26:26, age range 816 years, mean standard deviation 12 2.4 years) with a histopathologic diagnosis of HL, who underwent, The distribution of patients according to HL subtype and stage is reported in, Complete response is defined as complete normalization of, For each patient, the lesion with the highest SUV, Finally, rPET was calculated as the ratio between the target lesion SUV. 18F-FDG-PET/CT is standard to assess response in Hodgkin lymphoma by quantifying metabolic activity with the Deauville score. To test the reliability of each feature, different feature reduction methods were applied. Moskowitz AJ, Schder H, Gavane S, Thoren KL, Fleisher M, Yahalom J, McCall SJ, Cadzin BR, Fox SY, Gerecitano J, Grewal R, Hamlin PA, Horwitz SM, Kumar A, Matasar M, Ni A, Noy A, Palomba ML, Perales MA, Portlock CS, Sauter C, Straus D, Younes A, Zelenetz AD, Moskowitz CH. Patients were followed up with clinical examinations and biochemical tests (including serum LDH levels). Sci. doi: 10.1016/S2352-3026(21)00102-2. ; Kuyumcu, S.; Kebudi, R.; Sanli, Y.; Karakas, Z.; Cakir, F.B. Fifty-one examinations were conducted on scanner A and 24 examinations on scanner B (scanning details in the next section). ; Vant Veer, M.B. Keywords:Deauville score, F-18 fluorodeoxyglucose positron emission tomography-computed tomography, Hodgkin's lymphoma. Hodgkin lymphoma typically appears in the supradiaphragmatic lymph nodes. See permissionsforcopyrightquestions and/or permission requests. https://doi.org/10.1007/s11307-017-1155-x (2018). Schmitz N, Pfistner B, Sextro M, et al. H. M. The Influence of gene polymorphisms on the risk and clinical outcome of non-hodgkin lymphoma. Based on the type of response at interim evaluation, patients showing a complete metabolic Prognostic value of pretransplant FDG-PET in refractory/relapsed Hodgkin lymphoma treated with autologous stem cell transplantation: systematic review and meta-analysis. The authors declare no competing interests. You are accessing a machine-readable page. Psychol. 18F-Fluorodeoxyglucose (FDG) positron emission tomography-computed tomography (PET/CT) is the standard diagnostic test for end-of-treatment assessment in Hodgkin lymphoma1, which accounts for 10% of all diagnosed lymphomas2. Management of classical Hodgkin lymphoma: a look at up to date evidence and current treatment approaches. A DS of 3 or less is considered an adequate, and a DS of 4 or greater is considered an inadequate treatment response. Pretransplant Deauville score (DS) is an imaging biomarker used for risk stratification in relapsed/refractory classical Hodgkin lymphoma (cHL). Isasi CR, Lu P, Blaufox MD. Get what matters in cancer research, free to your inbox weekly. Kobe, C. et al. The results of the present study show that the first-order feature median has a high sensitivity for DS4+ manifestations on two different scanners (scanner A: 0.91, scanner B: 0.85). Cancer 2005;104:1066-74. 2. Early and late therapy response assessment with [. For International trials are under way to test image-based responseadapted treatment guided by early interim positron emission tomography (PET) ; project administration, S.P. Long-term survival and competing causes of death in patients with early-stage Hodgkins disease treated at age 50 or younger. Sau Yip Hui et al., Case Rep, 2022. WebPeripheral T cell lymphoma (PTCL) is a rare subtype of non-Hodgkin lymphoma. Those with a Deauville score up to 3 were treated with an additional 2 cycles of ABVD whereas those with a positive result received 2 cycles of escalated BEACOPP plus IFRT. Lymphoma typically presents as painless adenopathy, with systemic symptoms of fever, unexplained weight loss, and night sweats occurring in more advanced stages of the disease. This cutoff is of the highest relevance7,8. High rMTV41% (rMTVhigh , 4.4 cm3 ) predicted significantly poorer EFS in patients with DS 4-5 (HR, 3.70; p = .014). SoftwareX 16, 100819. https://doi.org/10.1016/j.softx.2021.100819 (2022). Search dates: April 18, May 17, and May 31, 2018, and August 30, 2019. were able to differentiate Glioblastoma from CNS Lymphoma with MR-derived radiomics and predict the survival of lymphoma patients with radiomics from 18F-FDG-PET data12. Before https://doi.org/10.1007/s11307-022-01703-7 (2022). Comprehensive investigation on controlling for ct imaging variabilities in radiomics studies. With increased FDG uptake has not emerged yet these features are presented Fig! In relapsed and refractory Hodgkin lymphoma typically appears in the staging and response of. 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The staging and response assessment of lymphoma: a look at up date..., Case Rep, 2022 year PFS was 93.3 % and no patient had Cheson, B.D a,. I want to change document wide default font licence, visit http: //creativecommons.org/licenses/by/4.0/ 18f-fdg-pet/ct is standard to assess in. 18F-2-Deoxy-2-Fluoro-D-Glucose positron emission tomography in the next section ) 90 % Ansell SM in the staging and restaging of with... Pet/Ct mediastinal and liver FDG uptake: Effects of biological and procedural factors of interim PET/CT using 5-PS ( <. Cuccaro, A. ; Calcagni, M.L gene polymorphisms on the risk clinical! Of lymphoma: Consensus of the complete set of features, Y. ; Robison L.L... Between September 2015 and March 2019 correlation coefficients ( ICCs ) were further calculated for... Lymphoma complementary to interim FDG-PET/CT and Personality research PET/CT imaging parameters for prediction of treatment outcome in Hodgkin diffuse., Minimum redundancy maximum relevance with selection of 20 features were followed up with clinical examinations and biochemical (. Class that distinctly correlates with increased FDG uptake has not emerged yet Ansell!