Jun kinase modulates tumor necrosis factor-dependent apoptosis in liver cells. PLoS One. 2011 Aug; 35(8):1509-18. J Gastroenterol Hepatol. J Biol Chem. 2006 Apr; 290(4):G583-9. Vasopressin inhibits type-I collagen and albumin gene expression in primary cultures of adult rat hepatocytes. 2010 Oct; 52(4):1390-400. Gastroenterology. Frequency of C9orf72 and SOD1 mutations in 302 sporadic ALS patients from three German ALS centers. Adv Second Messenger Phosphoprotein Res. Hydrogen peroxide-induced liver cell necrosis is dependent on AP-1 activation. Gastroenterology. Colmenero J, Bataller R, Sancho-Bru P, Domnguez M, Moreno M, Forns X, Bruguera M, Arroyo V. CCR2 promotes hepatic fibrosis in mice. 2016; 34(5):589-96. Study of factors causing excess protoporphyrin accumulation in cultured skin fibroblasts from patients with protoporphyria. Chojkier M, Flaherty M, Peterkofsky B, Majmudar GH, Spanheimer RG. Proc Natl Acad Sci U S A. Cell Metab. 2015 Jul; 22(7):512-8. 2019 07 23; 116(30):15184-15193. J Hepatol. Cell Metab. The mitochondrial permeability transition in cell death: a common mechanism in necrosis, apoptosis and autophagy. Kim YS, Schwabe RF, Qian T, Lemasters JJ. Regulation of alpha1(I) collagen messenger RNA decay by interactions with alphaCP at the 3'-untranslated region. Hepatitis C and alcohol: fundamental and translational research directions. Moderate alcohol drinking: effects on the heart and liver. Dig Dis. 2008 Jul; 255(7):993-1000. 2000 Apr 21; 275(16):12207-13. 2005 Sep-Oct; 7(9-10):1346-55. 2011 May; 53(5):1730-41. Am J Pathol. Gastroenterology. Arch Biochem Biophys. The fecal microbiome of ALS patients. Cell Mol Gastroenterol Hepatol. 2019 10; 68(10):1884-1892. Am J Physiol. Hum Mol Genet. Gastroenterology. J Bioenerg Biomembr. Liedtke C, Plmpe J, Kubicka S, Bradham CA, Manns MP. Nucleic Acids Res. Am J Physiol Gastrointest Liver Physiol. 2021; 12(3):891-920. 2014 Aug 12; 111(32):E3297-305. Dr. David Brenner, UCSDs vice chancellor of health sciences, told the San Diego Union-Tribune on Tuesday that the dispute was never about Aisen. Iimuro Y, Nishio T, Morimoto T, Nitta T, Stefanovic B, Choi SK. Delivery of matrix metalloproteinase-1 attenuates established liver fibrosis in the rat. Double-strand gap repair results in homologous recombination in mouse L cells. J Clin Exp Hepatol. Interleukin-6 increases rat metalloproteinase-13 gene expression through stimulation of activator protein 1 transcription factor in cultured fibroblasts. Staging of fibrosis in experimental non-alcoholic steatohepatitis by quantitative molecular imaging in rat models. Lang PA, Xu HC, Grusdat M, McIlwain DR, Pandyra AA. Zhang M, Haughey M, Wang NY, Blease K, Kapoun AM, Couto S, Belka I, Hoey T, Groza M, Hartke J, Bennett B, Cain J, Gurney A, Benish B, Castiglioni P, Drew C, Lachowicz J, Carayannopoulos L, Nathan SD, Distler J. J Biol Chem. FASEB J. 1998 Oct; 27(3):192-8. Miura K, Yoshino R, Hirai Y, Goto T, Ohshima S, Mikami K, Yoneyama K, Watanabe D, Sato M, Senoo H, Kodama Y, Osawa Y. Primary Alcohol-Activated Human and Mouse Hepatic Stellate Cells Share Similarities in Gene-Expression Profiles. Brenner has also been listed as a lead researcher on UCSDs portion of the liver study. 2011 Jan; 53(1):4-6. Inhibition of NFkappaB in activated rat hepatic stellate cells by proteasome inhibitors and an IkappaB super-repressor. Nishiura T, Nishimura T, deSerres S, Godfrey V, Bradham CA, Nakagawa T. Role of Kupffer cells and gut-derived endotoxins in alcoholic liver injury. Patel NS, Hooker J, Gonzalez M, Bhatt A, Nguyen P, Ramirez K. The characteristics of activated portal fibroblasts/myofibroblasts in liver fibrosis. PLoS One. Biofactors. A dual reporter gene transgenic mouse demonstrates heterogeneity in hepatic fibrogenic cell populations. 1990 Nov; 26(11):1011-23. To see the data as text. Molecular mechanisms of alcohol-induced hepatic fibrosis. Arch Clin Biomed Res. Hepatology. 2007 Dec 07; 249(3):518-31. 2017 Jun 30; 127(7):2697-2704. J Biol Chem. The gut-liver axis and the intersection with the microbiome. Sam F, Sawyer DB, Xie Z, Chang DL, Ngoy S. Hepatic stellate cells as a target for the treatment of liver fibrosis. Uzawa K, Grzesik WJ, Nishiura T, Kuznetsov SA, Robey PG. 2015 Sep; 42(5):582-90. J Immunol. Infect Immun. Aoyama T, Paik YH, Watanabe S, Laleu B, Gaggini F, Fioraso-Cartier L, Molango S, Heitz F, Merlot C, Szyndralewiez C, Page P. Liver carcinogenesis: rodent models of hepatocarcinoma and cholangiocarcinoma. 2007 Dec; 47(6):834-43. J Gastroenterol Hepatol. J Cell Biol. 2011 Jan; 53(1):96-105. Int J Stroke. 1989 Aug 11; 17(15):6055-64. Hum Gene Ther. 2001 Sep; 25(9):1360-7. Mazagova M, Wang L, Anfora AT, Wissmueller M, Lesley SA. 1992 Jun; 50(6):1203-10. David A. Brenner, MD, has served as Vice Chancellor of Health Sciences and Dean of the School of Medicine at UC San Diego since 2007. Am J Physiol. Proc Natl Acad Sci U S A. 2005 May; 41(5):1046-55. Schrum LW, Bird MA, Salcher O, Burchardt ER, Grisham JW. Best Pract Res Clin Gastroenterol. 2000 Aug; 119(2):446-60. Nuclear factor-kappaB in the liver: friend or foe? 2013 Mar; 37(6):630-9. J Clin Invest. 2004 Jun; 135(6):619-28. 1998 09; 275(3):G387-92. Hellerbrand C, Jobin C, Licato LL, Sartor RB. J Biol Chem. Curr Pathobiol Rep. 2013 Sep; 1(3):209-214. Mallat A, Praux AM, Serradeil-Le Gal C, Raufaste D, Gallois C. Differential regulation of hepatocyte DNA synthesis by cAMP in vitro in vivo. Placebo-controlled trial of high-dose atorvastatin in patients with severe cerebral small vessel disease. 1996 Nov; 271(5 Pt 1):G780-90. Meng F, Wang K, Aoyama T, Grivennikov SI, Paik Y, Scholten D, Cong M, Iwaisako K, Liu X, Zhang M, ?sterreicher CH, Stickel F, Ley K. Origin of myofibroblasts in liver fibrosis. J Clin Invest. J Immunol. Bradham CA, Schemmer P, Stachlewitz RF, Thurman RG. Koch KS, Fletcher RG, Grond MP, Inyang AI, Lu XP. # # # Media Contact: Alma Fisher, 619-543-6163, alfisher@ucsd.edu Yan AW, Fouts DE, Brandl J, St?rkel P, Torralba M, Schott E. Role and cellular source of nicotinamide adenine dinucleotide phosphate oxidase in hepatic fibrosis. 2021; 12(1):293-320. J Gastroenterol Hepatol. De Minicis S, Rychlicki C, Agostinelli L, Saccomanno S, Trozzi L, Candelaresi C, Bataller R, Mill?n C. Gastroenterology's editors-in-chief: historical and personal perspectives of their editorships. Sanz S, Pucilowska JB, Liu S, Rodrguez-Ortigosa CM, Lund PK. Surgery. 2020; 144(8):400-412. Joint statement on missions and submissions of papers to AGA journals. Different mechanisms decrease hepatic collagen and albumin production in fasted rats. Stem Cells Cloning. Their daughter, Laura, is a medical student at Columbia and their son, Nathan, attends the GIV/Girdin is a central hub for profibrogenic signalling networks during liver fibrosis. J Natl Cancer Inst. 2008 Sep; 5(9):496-7. Exp Biol Med (Maywood). 2007 Aug; 22(8):1256-64. Lab Invest. Cell Death Differ. M2-like macrophages are responsible for collagen degradation through a mannose receptor-mediated pathway. The CAAX 2016 Feb 10; 19(2):227-39. Agreement between TOAST and CCS ischemic stroke classification: the NINDS SiGN study. 1997 Jan 17; 272(3):1753-60. Biochem Biophys Res Commun. 2020 Nov 03; 32(5):901. Kodama Y, Taura K, Miura K, Schnabl B, Osawa Y. Molecular pathogenesis of liver fibrosis. Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance. Protection from liver fibrosis by a peroxisome proliferator-activated receptor d agonist. Vice Chancellor, UC San Diego Health Sciences. Dr. David Brenner is vice chancellor for health sciences at the University of California, San Diego. In this role, he leads the School of Medicine, Skaggs School of Pharmacy and Pharmaceutical Sciences at University of California, San Diego, and UC San Diego Health. 1999; 8(3):151-63. Is it the end of the line for the EMT? J Clin Invest. The role of Smad3 in mediating mouse hepatic stellate cell activation. A role for lipid peroxidation? Koyama Y, Wang P, Liang S, Iwaisako K, Liu X, Xu J, Zhang M, Sun M, Cong M, Karin D, Taura K. Liver inflammation and fibrosis. Kagnoff MF, Omary MB, de Grandpre LY, Roebuck KA, Richman DD. 2017 09 15; 331:135-141. 2008 Apr 15; 5(3):338-42. 2011 Jul; 179(1):189-98. To a large degree, it was sparked by Dr. David Brenner, UC San Diegos vice chancellor for health sciences. Targeted disruption of the mouse ferrochelatase gene producing an exon 10 deletion. Gastroenterology. 2021 11; 25(11):2149-2159. 2012 Nov; 122(11):4280-2. 2020 02 13; 5(3). 2003 Nov; 112(9):1383-94. 2000 Nov 01; 28(21):4306-16. Ezetimibe for the treatment of nonalcoholic steatohepatitis: assessment by novel magnetic resonance imaging and magnetic resonance elastography in a randomized trial (MOZART trial). 2004 Dec; 127(6):1659. Biochem Biophys Res Commun. Am J Physiol Heart Circ Physiol. 1999 Apr 15; 162(8):4447-54. L-glutamine and L-asparagine stimulate ODC activity and proliferation in a porcine jejunal enterocyte line. 1987 Dec 25; 262(36):17690-5. 2010 Feb 25; 3:39-47. 1998 Jul; 43(7):1454-64. Idh1 protects murine hepatocytes from endotoxin-induced oxidative stress by regulating the intracellular NADP(+)/NADPH ratio. 2010 Jul-Aug; 19(4):311-20. 2003 Nov; 285(5):G949-58. 1988 Sep-Oct; 8(5):1040-5. Contribution of bone marrow-derived fibrocytes to liver fibrosis. J Hepatol. Nephron. JCI Insight. 1995 Jul; 22(1):241-51. 1994 Sep; 17(3):410-2. Am J Physiol Gastrointest Liver Physiol. Clin Gastroenterol Hepatol. 2002 Aug 15; 100(4):1470-7. Front Mol Biosci. An exon 10 deletion in the mouse ferrochelatase gene has a dominant-negative effect and causes mild protoporphyria. WebDavidBrenner, M.D., a distinguished physician-scientist, is Vice Chancellor for Health Sciences and Dean of the School of Medicine at the University of California, San Diego, effective Tacke F, Gbele E, Bataille F, Schwabe RF, Hellerbrand C, Klebl F, Straub RH, Luedde T, Manns MP, Trautwein C. The genetics of nonalcoholic fatty liver disease. Investigating the role of the extracellular environment in modulating hepatic stellate cell biology with arrayed combinatorial microenvironments. Westwick JK, Fleckenstein J, Yin M, Yang SQ, Bradham CA. Nat Rev Gastroenterol Hepatol. J Hepatol. 2007 Feb; 27(1):28-43. J Immunol. 2007 Jun 15; 462(2):266-72. 1994 Jun 21; 91(13):6030-4. Lehmann TG, Luedde T, Schwabe RF, Bunzendahl H, Samulski RJ, Lemasters JJ. 2020 05; 72(5):946-959. Norepinephrine induces calcium spikes and proinflammatory actions in human hepatic stellate cells. Westwick JK, Cox AD, Der CJ, Cobb MH, Hibi M. Mithramycin selectively inhibits collagen-alpha 1(I) gene expression in human fibroblast. Taura K, Miura K, Iwaisako K, Osterreicher CH, Kodama Y, Penz-Osterreicher M. Reduction of advanced liver fibrosis by short-term targeted delivery of an angiotensin receptor blocker to hepatic stellate cells in rats. Semin Liver Dis. Adachi M, Osawa Y, Uchinami H, Kitamura T, Accili D. Systemic mediators induce fibrogenic effects in normal liver after partial bile duct ligation. HIV-1 infection and expression in human colonic cells: infection and expression in CD4+ and CD4- cell lines. PLoS One. Gratte FD, Pasic S, Abu Bakar NDB, Gogoi-Tiwari J, Liu X, Carlessi R. The genetic landscape of axonal neuropathies in the middle-aged and elderly: Focus on MME. Proc Natl Acad Sci U S A. Rhoads JM, Argenzio RA, Chen W, Graves LM, Licato LL, Blikslager AT, Smith J, Gatzy J. Ceramide activates the stress-activated protein kinases. 2013 Jul; 145(1):16-31. In vivo activation of mitogen-activated protein kinases in rat intestinal neoplasia. Hatano E, Bennett BL, Manning AM, Qian T, Lemasters JJ. Detection of polycyclic aromatic hydrocarbon-DNA adducts in white blood cells of foundry workers. 2005 Nov; 29(11 Suppl):102S-109S. Pizza V, Antonini P, Marino R, D'Arena G, Lucibello SG, Rizzo M. Functional Microbial Responses to Alcohol Abstinence in Patients With Alcohol Use Disorder. Exp Biol Med (Maywood). Activation of activating protein 1 during hepatic acute phase response. Human hepatic stellate cell isolation and characterization. The role of human cytochrome P450 2E1 in liver inflammation and fibrosis. Hepatic stellate cells primed with cytokines upregulate inflammation in response to peptidoglycan or lipoteichoic acid. 2006 Apr; 43(4):872-8. Report of the American Gastroenterological Association (AGA) Institute Obesity Task Force. Brenner succeeds Kristiina Vuori, M.D., Ph.D., who announced her intention to step down as president in January after serving in the role for the past 12 years. Gbele E, Reif S, Tsukada S, Bataller R, Yata Y, Morris T, Schrum LW. Hepatology. Zhong Z, Schwabe RF, Kai Y, He L, Yang L, Bunzendahl H. NADPH oxidase in the liver: defensive, offensive, or fibrogenic? The role of p70S6K in hepatic stellate cell collagen gene expression and cell proliferation. Scholarship Fund, Molecular Pathogenesis of Apoptosis in Liver Cells, ONCOGENIC K-RAS INDUCTION OF GASTRIN GENE TRANSCRIPTION, GENE TECHNOLOGY THERAPY AND ALCOHOL-INDUCED FIBROSIS, The Southern California Research Center for ALPD and Cirrhosis, Molecular and Cellular Pathogenesis in Alcoholism, MOLECULAR AND CELLULAR PATHOGENESIS IN ALCOHOLISM, FUNCTION OF NUCLEAR ONCOGENES IN CANCER CELLS, Molecular Mechanisms by which TNFalpha Modulates Fibrosis. Role of NADPH oxidases in liver fibrosis. 2013 Mar 01; 3(1):4-11. Gastroenterology. What goes up must come down: the emerging role of microRNA in fibrosis. Ferrochelatase cDNA delivered by adenoviral vector corrects biochemical defect in protoporphyric cells. Free cholesterol-loaded macrophages are an abundant source of tumor necrosis factor-alpha and interleukin-6: model of NF-kappaB- and map kinase-dependent inflammation in advanced atherosclerosis. Dig Dis. Multiplex short tandem repeat profiling of immortalized hepatic stellate cell line Col-GFP HSC. 1998 Nov; 18(11):6353-64. Corn oil rapidly activates nuclear factor-kappaB in hepatic Kupffer cells by oxidant-dependent mechanisms. Gastroenterology. Signal transduction during liver regeneration. Floch MH, Walker WA, Sanders ME, Nieuwdorp M, Kim AS. 2001 Aug; 21(3):437-51. 2009 Jan 16; 378(3):348-53. Comparison of human and bovine protoporphyria. Neurology. 2019 03 29; 10(1):1406. 1998 Feb; 2(1):77-102, vi. 2012 Apr; 56(4):965-72. Allergy. 2010 Feb; 16(2):181-90. NADPH oxidase mediated oxidative stress in hepatic fibrogenesis. Prog. J Gastroenterol Hepatol. 2022 07 05; 34(7):978-990.e4. Fibrogenesis and type I collagen gene regulation. CCR1 and CCR5 promote hepatic fibrosis in mice. 1998 Sep; 13(S1):S39-S50. Black D, Bird MA, Hayden M, Schrum LW, Lange P, Samson C, Hatano E, Rippe RA. Gastroenterology. Circulation. Hepatology. HBO Special recorded in Las What is the potential role of antifibrotic agents for the treatment of liver disease? J Gastroenterol Hepatol. Differentiation. This graph shows the total number of publications by year. Cong M, Zhao W, Liu T, Wang P, Fan X, Zhai Q, Bao X, Zhang D, You H. Radiation exposure from depleted uranium: The radiation bystander effect. Am J Physiol. Cytokine polymorphisms associated with carotid intima-media thickness in stroke patients. Carvalho-Gontijo R, Han C, Zhang L, Zhang V, Hosseini M. Aberrant iron distribution via hepatocyte-stellate cell axis drives liver lipogenesis and fibrosis. 2009 Mar 03; 106(9):3300-5. J Biol Chem. Aliment Pharmacol Ther. Systemic infusion of angiotensin II exacerbates liver fibrosis in bile duct-ligated rats. 2006 Aug; 116(8):2058-9. Gut. MELD and the practicing gastroenterologist. 2017 01; 65(1):78-88. 1991 Mar; 5(3):275-81. J Biol Chem. Researchers can. 5' stem-loop of collagen alpha 1(I) mRNA inhibits translation in vitro but is required for triple helical collagen synthesis in vivo. 2011 Jan 04; 108(1):308-13. J Biol Chem. Hepatology. 2003 May; 37(5):1043-55. Nat Rev Gastroenterol Hepatol. 1993 Sep; 92(3):1336-48. 2019 03; 156(4):1156-1172.e6. 1998 Jun; 42(6):779-87. Identifying nonalcoholic fatty liver disease patients with active fibrosis by measuring extracellular matrix remodeling rates in tissue and blood. Clin Res Hepatol Gastroenterol. 2005; 23(3-4):255-63. WebDavid Brenner is vice chancellor for health sciences at University of California San Diego. Liver Int. Enomoto N, Yamashina S, Schemmer P, Rivera CA, Bradford BU, Enomoto A. IkappaBalpha gene transfer is cytotoxic to squamous-cell lung cancer cells and sensitizes them to tumor necrosis factor-alpha-mediated cell death. Meng F, Wang J, Ge J, Fan X, Wang B, Han L. Innate immunity in alcoholic liver disease. Kandil HM, Argenzio RA, Chen W, Berschneider HM, Stiles AD, Westwick JK, Rippe RA. 2011 Oct; 89(10):997-1013. J Immunol. Next-generation academic medicine. J Gastroenterol. 2016; 7:17. 2005; 23(3-4):264-74. Hepatology. Of Mice and Men and Nonalcoholic Steatohepatitis. Pronase destroys the lipopolysaccharide receptor CD14 on Kupffer cells. Semin Liver Dis. Luedde T, Rodriguez ME, Tacke F, Xiong Y. Data from arrays: an embarrassment of riches. Hepatitis C virus core and nonstructural proteins induce fibrogenic effects in hepatic stellate cells. Gastroenterology. Hepatology. I. TNF-alpha-induced liver injury: role of IKK, JNK, and ROS pathways. Type I collagen gene regulation and the molecular pathogenesis of cirrhosis. 2019 Feb; 3(2):180-192. Activated hepatic stellate cells and portal fibroblasts contribute to cholestatic liver fibrosis in MDR2 knockout mice. 1992 Sep 04; 70(5):777-89. The glutathione precursor L-2-oxothiazolidine-4-carboxylic acid protects against liver injury due to chronic enteral ethanol exposure in the rat. Sp1 binding activity increases in activated Ito cells. Magnetic resonance elastography identifies fibrosis in adults with alpha-1 antitrypsin deficiency liver disease: a prospective study. Hepatol Commun. Cox AD, Garcia AM, Westwick JK, Kowalczyk JJ, Lewis MD. Antiapoptotic effect of c-Jun N-terminal Kinase-1 through Mcl-1 stabilization in TNF-induced hepatocyte apoptosis. Iwaisako K, Jiang C, Zhang M, Cong M, Moore-Morris TJ, Park TJ, Liu X, Xu J, Wang P, Paik YH, Meng F, Asagiri M, Murray LA. A method for in vitro DNase I footprinting analysis on supercoiled templates. 2009 May; 40(5):1721-8. Achievement of optimal medical therapy goals for U.S. adults with coronary artery disease: results from the REGARDS Study (REasons for Geographic And Racial Differences in Stroke). 2007 Aug; 47(2):307-9. 2000 Feb; 88(2):142-9. Antifibrotic effects of a tissue inhibitor of metalloproteinase-1 antibody on established liver fibrosis in rats. Signal transduction during liver regeneration. 2014 Jul; 124(7):2921-34. 1998 Feb 15; 101(4):802-11. Li Y, Schwabe RF, DeVries-Seimon T, Yao PM, Gerbod-Giannone MC, Tall AR, Davis RJ, Flavell R. JNK mediates hepatic ischemia reperfusion injury. 1985 Apr; 5(4):684-91. Expression of small heat shock protein alphaB-crystallin is induced after hepatic stellate cell activation. Clin Gastroenterol Hepatol. 2007 Jun; 132(7):2601-4. 1998 10; 275(4):C1058-66. Cellular and molecular biology of hepatocyte growth, regeneration and gene expression. Association between novel MRI-estimated pancreatic fat and liver histology-determined steatosis and fibrosis in non-alcoholic fatty liver disease. 2020; 4(5):561-580. 2011 Jul; 31(6):762-72. 2017 Aug; 40(2):454-464. 2008 Aug; 42(5):349-61. PLoS One. Pharm Res. 2014 May; 146(6):1513-24. J Lab Clin Med. Awareness, treatment, and control of vascular risk factors among stroke survivors. Enomoto N, Yamashina S, Kono H, Schemmer P, Rivera CA, Enomoto A, Nishiura T, Nishimura T. TNF receptor-associated factor-2 is involved in both IL-1 beta and TNF-alpha signaling cascades leading to NF-kappa B activation and IL-8 expression in human intestinal epithelial cells. Acetaldehyde increases collagen gene transcription in cultured human fibroblasts. 2015 Sep; 39 Suppl 1:S75-9. Methods Mol Biol. 2010 Oct; 8(10):891-8, 898.e1-2. Pericytes and perivascular fibroblasts are the primary source of collagen-producing cells in obstructive fibrosis of the kidney. The accuracy of patient-reported measures for GI symptoms: a comparison of real time and retrospective reports. Gastroenterol Res Pract. Proc Am Thorac Soc. medRxiv. Hepatology. 2005 Mar; 39(3):181-8. 2007 May; 132(6):2272-5. 1999 Aug; 21(2):238-45. J Gastroenterol Hepatol. J Gastroenterol Hepatol. 2003 Mar; 37(3):493-503. 2011 Apr; 300(4):G516-25. Hellerbrand C, Jobin C, Iimuro Y, Licato L, Sartor RB. J Hepatol. Nature. This graph shows the number and percent of publications by field. Sancho-Bru P, Juez E, Moreno M, Khurdayan V, Morales-Ruiz M, Colmenero J, Arroyo V. Angiotensin-converting-enzyme 2 inhibits liver fibrosis in mice. 2003 Apr 15; 170(8):4053-60. 1984; 49:151-60. 2006 Sep; 45(3):429-38. University of California San Diego named John M. 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